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The protective effects of HDL are linked to the enzyme paraoxonase 1 (PON1), which catalyzes anti-oxidative reactions through its arylesterase (AE) activity. Furthermore, 95% of PON1 found in the serum is bound to HDL through the formation of an HDL-PON1 complex. This complex is partially regulated by the phospholipase endothelial lipase (EL). This enzyme hydrolyzes […]

Diversity in clinical trials is an important issue as the effectiveness of a drug in one population doesn’t always indicate that it will be as effective in other populations or that it will even be safe in other groups. If a drug is approved to be effective and is licensed for a disease it is